| Customization: | Available |
|---|---|
| Certification: | ISO, FDA |
| Assay Method: | HPLC, UV |
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Description:
Ergothioneine is a potent, naturally derived antioxidant with unique cellular protection properties. Recognized for its "longevity vitamin" status, it neutralizes free radicals, mitigates oxidative stress, and supports mitochondrial function. Its exceptional stability and ability to accumulate in tissues make it ideal for anti-aging formulations, nutraceuticals, and cosmeceuticals.
Ergothioneine (EGT) is the betaine of 2-thiohistidine (2-thioHis) and may be the last undiscovered vitamin. EGT cannot be incorporated into a peptide since the α-nitrogen is trimethylated, although this would be advantageous as an EGT-like moiety in a peptide would impart unique antioxidant and metal chelation properties. The amino acid 2-thioHis is an analogue of EGT and can be incorporated into a peptide, although there is only one reported occurrence of this in the literature. A likely reason is the harsh conditions reported for protection of the thione, with similarly harsh conditions used in order to achieve deprotection after synthesis. Here, we report a novel strategy for the incorporation of 2-thioHis into peptides in which we decided to leave the thione unprotected. This decision was based upon the reported low reactivity of EGT with 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB), a very electrophilic disulfide. This strategy was successful, and we report here the synthesis of 2-thioHis analogues of carnosine (βAH), GHK-tripeptide, and HGPLGPL. Each of these peptides contain a histidine (His) residue and possesses biological activity. Our results show that substitution of His with 2-thioHis imparts strong antioxidant, radical scavenging, and copper binding properties to the peptide. Notably, we found that the 2-thioHis analogue of GHK-tripeptide was able to completely quench the hydroxyl and ABTS radicals in our assays, and its antioxidant capacity was significantly greater than would be expected based on the antioxidant capacity of free 2-thioHis. Our work makes possible greater future use of 2-thioHis in peptides.
Superior Antioxidant Activity
Scavenges hydroxyl radicals, peroxynitrite, and singlet oxygen with higher efficacy than glutathione and vitamin C.
Protects collagen, elastin, and DNA from UV-induced degradation, reducing wrinkles and hyperpigmentation.
Anti-Aging & Skin Barrier Support
Enhances skin hydration and resilience by modulating Nrf2 pathways.
Clinically proven to reduce MMP-1 (collagenase) expression by 40% at 0.05% concentration.
Systemic Health Benefits
Supports liver detoxification, cognitive health, and cardiovascular function.
Synergizes with other antioxidants (e.g., glutathione, vitamin E) for enhanced cellular protection.
Application Fields:
Cosmeceuticals: Serums, creams, sunscreens, and eye creams targeting UV protection and anti-aging.
Nutraceuticals: Capsules, powders for longevity and oxidative stress management.
Functional Foods: Fortified beverages, energy bars.
| Parameter | Details |
|---|---|
| Product Name | Premium Cosmetic Grade 99% Ergothioneine |
| Appearance | White to off-white crystalline powder |
| Solubility | Water-soluble (≥50 mg/mL at 25°C) |
| Particle Size | 80–120 mesh |
| Heavy Metals | ≤10 ppm (Pb, As, Cd, Hg) |
| Microbial Limits | Total Plate Count <100 CFU/g |
| Certifications | ISO 9001, Halal, Kosher, Vegan |
| Storage | 2–8°C in airtight, light-resistant containers |
| Shelf Life | 36 months |
Hubei Sanxin Pharmaceutical Technology Co., Ltd is a wholly-owned subsidiary of Hubei Sanxin Biotechnology Co., Ltd. Which was established in March 2011, located in Dongcheng Industrial Park, Fangxian, Shiyan City. Our company owns first -class production equipment with the latest technology and testing methods. We specialize in scientific research, development, production, and sales all as one national high-tech enterprise, We also be known for agricultural leading enterprises in Shiyan City. We have GMP planting base with more than 4942 acres, 2 automatic production lines, which can produce more than 800 tons of plant extracts annually. The company has passed FDA certification and Kosher and Halal certification.
Sanxin′s main products are: Polygonum Cuspidatum Extracts (resveratrol, Polydatin, emodin, Physcion and proportional extracts of Polygonum cuspidatum); Pueraria Extracts (pueraria isoflavones, puerarin); Olive Leaf Extract(Oleuropein, Hydroxytyrosol); Tea extract; Baicalin and other standard extracts and proportional extract products. Our products have been widely used in food, health care products, medicines, cosmetics, veterinary medicine, feed additives and many other fields. Now company′s products have been sold to Hunan, Tianjin, Beijing, Shanghai and other places, some of the products have been exported to the United States, Canada, UK, Japan, and other more than 30 countries. Sanxin company′s main spirit is: Be honest be Trustworthy, win-win cooperation! Welcome to our company!
For more information, samples, or to place an order, please contact us. We look forward to partnering with you to deliver high-quality resveratrol powder that meets your needs!
Premium Quality: Cold-pressed extraction ensures high nutrient retention and purity.
Global Certifications: Complies with international standards for safety and quality.
Custom Solutions: Tailored formulations, concentrations, and packaging options available.
Competitive Pricing: High-quality products at cost-effective prices.
Fast Delivery: Reliable logistics with global shipping options.
Is ergothioneine safe for topical and oral use?
Yes. Recognized as GRAS (Generally Recognized As Safe) by FDA and EFSA. Non-irritating at concentrations ≤1%.
How does ergothioneine differ from vitamin C or E?
Unlike vitamins, ergothioneine has a dedicated transporter (OCTN1), ensuring targeted delivery to cells. It remains stable under heat and light, unlike vitamin C.
Who should use ergothioneine?
Ideal for aging populations, individuals with high oxidative stress (e.g., smokers, athletes), and sensitive skin types seeking gentle antioxidants.
Can it be combined with other actives?
Yes. Synergizes with hyaluronic acid, niacinamide, and peptides. Avoid mixing with strong acids (pH <3) to prevent degradation.
What is the recommended dosage?
Topical: 0.01-0.5% in formulations.
Oral: 5-30 mg/day for nutraceuticals.
Is it vegan-friendly and sustainably sourced?
Yes. Produced via biofermentation (non-animal derived) with ISO 14001-certified processes.
Are there clinical studies supporting its efficacy?
Over 50 peer-reviewed studies confirm benefits in skin aging, cognitive decline, and metabolic health.
Where is it regulated?
Approved in EU, US, and Japan. Compliant with ISO 16128 for natural origin claims.
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