| Customization: | Available |
|---|---|
| Certification: | ISO, FDA, Halal |
| Assay Method: | HPLC, UV |
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Product Name:Troxerutin 95% Sophora Japonica Extract
Botanical Source: Sophora japonica L. (Pagoda Tree Flower Buds)
Active Standardization: ≥95% Troxerutin (Trihydroxyethylrutin)
CAS No.: 7085-55-4
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO, Vegan
Positioning: Pharmaceutical-Grade Venotropic Agent for Microcirculation & Oxidative Stress Management
Troxerutin is a premium extract derived from organic Sophora japonica flower buds via low-temperature solvent extraction and crystallization purification, standardizing ≥95% troxerutin-a semi-synthetic derivative of rutin with superior bioavailability and vascular tropism. This water-soluble powder (solubility: 8.5 g/100mL) delivers triple-action bioactivity:
Microcirculation Enhancement: Reduces capillary permeability by 40% via hyaluronidase inhibition and endothelial barrier stabilization.
Antioxidant Defense: ORAC value 28,000 μmol TE/g-neutralizes ROS and chelates Fe²+/Cu+ ions, preventing LDL oxidation.
Anti-Inflammatory Action: Suppresses TNF-α/ICAM-1 pathways, decreasing edema by 35% in clinical models.
Ideal for nutraceutical and cosmeceutical formulations requiring validated vascular protection.
Nutraceuticals:
Chronic Venous Insufficiency (CVI): Capsules/tablets (1,000-1,500 mg/day) reducing edema and capillary fragility.
Diabetic Microangiopathy: Synergizes with α-lipoic acid to inhibit glycation end-products.
Cosmeceuticals:
Redness-Reduction Serums: 0.5-2% concentrations decrease UV-induced erythema by 52%.
Anti-Aging Creams: Protects collagen via MMP-9 inhibition and elastin synthesis upregulation.
Clinical Formulations:
Hemorrhoid Management: OTC gels/pessaries for vascular inflammation relief.
Functional Foods:
Fortified beverages for circulatory support (stable at pH 4-7; nanoemulsion formats available).
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Yellow-green crystalline powder | Visual |
| Troxerutin Content | ≥95% | HPLC-UV (USP 43) |
| Rutin Precursor | ≤2.0% | HPLC-DAD |
| Particle Size | 100% pass 80 mesh | Laser Diffraction |
| Solubility | ≥8.5 g/100mL in water | Gravimetric |
| Heavy Metals | Pb≤0.3 ppm, As≤0.2 ppm, Cd≤0.1 ppm | ICP-MS |
| Microbiology | TPC ≤500 CFU/g; Pathogens: Absent | ISO 4833-1/6579 |
| Pesticides | ND (EU MRLs) | GC-MS/MS |
| Residual Solvents | Ethanol ≤50 ppm | GC-FID |
| Shelf Life | 24 months (15-25°C, dark, dry conditions) | ICH Q1A |
Hubei Sanxin Pharmaceutical Technology Co., Ltd is a wholly-owned subsidiary of Hubei Sanxin Biotechnology Co., Ltd. Which was established in March 2011, located in Dongcheng Industrial Park, Fangxian, Shiyan City. Our company owns first -class production equipment with the latest technology and testing methods. We specialize in scientific research, development, production, and sales all as one national high-tech enterprise, We also be known for agricultural leading enterprises in Shiyan City. We have GMP planting base with more than 4942 acres, 2 automatic production lines, which can produce more than 800 tons of plant extracts annually. The company has passed FDA certification and Kosher and Halal certification.
Sanxin′s main products are: Polygonum Cuspidatum Extracts (resveratrol, Polydatin, emodin, Physcion and proportional extracts of Polygonum cuspidatum); Pueraria Extracts (pueraria isoflavones, puerarin); Olive Leaf Extract(Oleuropein, Hydroxytyrosol); Tea extract; Baicalin and other standard extracts and proportional extract products. Our products have been widely used in food, health care products, medicines, cosmetics, veterinary medicine, feed additives and many other fields. Now company′s products have been sold to Hunan, Tianjin, Beijing, Shanghai and other places, some of the products have been exported to the United States, Canada, UK, Japan, and other more than 30 countries. Sanxin company′s main spirit is: Be honest be Trustworthy, win-win cooperation! Welcome to our company!
For more information, samples, or to place an order, please contact us. We look forward to partnering with you to deliver high-quality resveratrol powder that meets your needs!
Seed-Sourced Purity:
Seed extraction yields 20%↑ bioactive retention vs. flowers due to lower enzymatic degradation.
Green Chemistry:
Ethanol/water-based process (no hexane; residue ≤50 ppm).
Vertical Integration:
Organic Sophora japonica farms in Shaanxi, China-blockchain traceability from soil to powder.
Stability Mastery:
Nitrogen-flushed aluminum packaging (peroxide value ≤2 meq/kg; rutin degradation ≤3% at 24M).
Certified Excellence:
ISO 22000, FDA GRAS dossier; Halal/Kosher/Non-GMO compliant.
Q1: How does troxerutin differ from rutin?
A1: Troxerutin is rutin's hydroxyethylated derivative, exhibiting 3x higher water solubility and 50% greater vascular bioavailability due to enhanced endothelial cell uptake.
Q2: What's the clinical dosage for venous edema?
*A2: 1,000-1,500 mg/day (standardized to 95% troxerutin). Studies show 40%↓ leg swelling at 8 weeks.
Q3: Stability in acidic topical formulations?
A3: Stable at pH 3-8. For pH <3, use nanoencapsulation to prevent glycosidic bond hydrolysis.
Q4: Safe for diabetic patients?
A4: Yes. Reduces retinal vascular leakage in diabetic retinopathy models. Monitor blood glucose if combined with antidiabetics.
Q5: Why flower buds over seeds?
A5: Buds yield 98% troxerutin purity vs. 85% in seeds, with lower enzymatic degradation during extraction.
Q6: Allergen and GMO status?
*A6: Gluten-free, non-GMO, vegan (ELISA/GC-MS verified). No soy, dairy, or nut derivatives.
Q7: How to authenticate troxerutin purity?
*A7: Batch-specific CoA includes:
HPLC-UV quantification (≥95%)
FTIR for hydroxyethyl group validation
Heavy metals/pesticides (ND)
Q8: Shelf life in liquid supplements?
*A8: 12 months with nitrogen flushing + cold storage (4°C). Avoid UV exposure to prevent photodegradation.
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