| Customization: | Available |
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| Certification: | ISO, FDA |
| Assay Method: | HPLC, UV |
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Product Name: Hesperidin 90% Citrus Aurantium Extract
Botanical Source: Citrus aurantium L. (Bitter Orange Peel)
Active Compound: ≥90% Hesperidin (Dihydroflavonoid Glycoside)
CAS No.: 520-26-3
Molecular Formula: C28H34O15
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO, GRAS
Hesperidin is a pharmaceutical-grade extract derived from organic bitter orange peel (Citrus aurantium) via proprietary subcritical water extraction (SWE) technology, standardizing ≥90% hesperidin-a potent dihydroflavonoid glycoside. This process preserves synergistic co-factors (including aurantiamarin and polymethoxyflavones) while eliminating solvent residues, enhancing bioavailability and bioactivity. Clinically validated for:
Vascular Integrity: Reduces capillary permeability by 45% via hyaluronidase inhibition and collagen stabilization.
Antioxidant Defense: ORAC value 24,000 μmol TE/g-scavenges ROS and chelates pro-oxidant metals (Fe²+, Cu+).
Hepatoprotection: Upregulates multidrug resistance protein 2 (Mrp2), lowering ALT/AST levels by 50% in chemical-induced liver injury.
Anti-Inflammatory Action: Suppresses TNF-α/COX-2 pathways, decreasing edema by 38% in vivo
Hubei Sanxin Pharmaceutical Technology Co., Ltd is a wholly-owned subsidiary of Hubei Sanxin Biotechnology Co., Ltd. Which was established in March 2011, located in Dongcheng Industrial Park, Fangxian, Shiyan City. Our company owns first -class production equipment with the latest technology and testing methods. We specialize in scientific research, development, production, and sales all as one national high-tech enterprise, We also be known for agricultural leading enterprises in Shiyan City. We have GMP planting base with more than 4942 acres, 2 automatic production lines, which can produce more than 800 tons of plant extracts annually. The company has passed FDA certification and Kosher and Halal certification.
Sanxin′s main products are: Polygonum Cuspidatum Extracts (resveratrol, Polydatin, emodin, Physcion and proportional extracts of Polygonum cuspidatum); Pueraria Extracts (pueraria isoflavones, puerarin); Olive Leaf Extract(Oleuropein, Hydroxytyrosol); Tea extract; Baicalin and other standard extracts and proportional extract products. Our products have been widely used in food, health care products, medicines, cosmetics, veterinary medicine, feed additives and many other fields. Now company′s products have been sold to Hunan, Tianjin, Beijing, Shanghai and other places, some of the products have been exported to the United States, Canada, UK, Japan, and other more than 30 countries. Sanxin company′s main spirit is: Be honest be Trustworthy, win-win cooperation! Welcome to our company!
For more information, samples, or to place an order, please contact us. We look forward to partnering with you to deliver high-quality resveratrol powder that meets your needs!
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Fine pale yellow powder | Visual |
| Hesperidin Content | ≥90% | HPLC-UV (USP 43) |
| Loss on Drying | ≤5% | Karl Fischer |
| Ash Content | ≤3% | AOAC 945.38 |
| Solubility | 1 g/50 L water (enhanced via nanoemulsion) | Gravimetric |
| Heavy Metals | Pb≤0.3 ppm, As≤0.2 ppm, Cd≤0.1 ppm | ICP-MS |
| Pesticide Residues | ND (EU MRLs) | GC-MS/MS |
| Microbiology | TPC ≤500 CFU/g; Pathogens: Absent | ISO 4833-1/6579 |
| Residual Solvents | Ethanol ≤50 ppm | GC-FID |
| Shelf Life | 24 months (15-25°C, dark, dry conditions) | ICH Q1A |
Nutraceuticals:
Venous Health Formulas: Capsules/tablets (500-1,000 mg/day) for edema reduction and capillary fragility.
Liver Detox Blends: Synergizes with NAC to mitigate drug-induced hepatotoxicity (e.g., alcohol, acetaminophen).
Functional Foods & Beverages:
Fortified juices and meal replacements for oxidative stress management (stable at pH 4-8; nanoemulsion recommended).
Cosmeceuticals:
Anti-Redness Serums: 0.5-2% concentrations inhibit UV-induced erythema and collagen degradation.
Anti-Aging Creams: Enhances skin elasticity via MMP-1 suppression.
Pharmaceutical Adjuvants:
Hypertension and diabetic retinopathy formulations (activates ACE inhibition).
Why Partner With Us?
Ethical Sourcing: Direct partnerships with Fair Trade-certified farms
Science-Backed: Full dossier with clinical studies and formulation guidelines
Competitive Pricing: 10-15% below market for 100+ kg orders
Global Logistics: DDP shipping to USA/EU/ASEAN with COA, MSDS, and shelf-life data
Seed-to-Powder Traceability: Vertical integration from organic farms to GMP facilities.
Advanced Stabilization: Nitrogen-flushed packaging to preserve volatile safranal.
Eco-Conscious Processing: Solar-powered extraction, zero-waste water recycling.
Strict QC Protocols: Every batch HPLC-tested for actives, heavy metals (<10 ppm), pesticides (ND), and microbes.
OEM/ODM Flexibility: Custom ratios (4:1 to 20:1), carrier-free options, and private labeling.
Q1: How does hesperidin compare to troxerutin for vascular support?
*A1: Hesperidin excels in capillary integrity and antioxidant synergy, while troxerutin (its semi-synthetic derivative) offers higher water solubility for acute edema management. Combining both provides comprehensive venous-arterial protection.
Q2: What is the evidence for hepatoprotective effects?
*A2: Clinical studies demonstrate 200 mg/kg hesperidin upregulates Mrp2 transporters, reducing ALT/AST by 50% in drug-induced liver injury models. This enhances toxin clearance and glutathione recycling.
Q3: Can it be used in acidic beverages without precipitation?
*A3: Native hesperidin has low water solubility (1g/50L). For clear beverages, use nanoemulsion formats (solubility ↑88x) or enteric-coated capsules.
Q4: Optimal dosage for antioxidant synergy?
*A4: 250-500 mg/day with vitamin C-hesperidin doubles ascorbic acid bioavailability by inhibiting its oxidation in enterocytes.
Q5: Safety profile during pregnancy?
*A5: GRAS-affirmed at ≤500 mg/day. Avoid high doses (>1g) due to potential uterine stimulation. Consult physicians for prenatal formulations.
Q6: How to verify botanical authenticity?
*A6: Batch-specific CoA includes DNA barcoding (ITS2 region), HPLC quantification of aurantiamarin markers, and pesticide residue screens.
Q7: Stability in topical formulations?
*A7: Stable at pH 3-8. For serums, combine with light-stabilizing agents (e.g., tocopherol) and avoid prolonged UV exposure.
Q8: Synergies with other flavonoids?
*A8: Combines with diosmin (4:1 ratio) for venous tone enhancement, or naringenin for amplified antioxidant pathways (↑SOD/GPx activity).
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