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| Assay Method: | HPLC, UV |
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Product Name: Organic Polygonatum Powder
Botanical Source: Polygonatum sibiricum Red. (Siberian Solomon's Seal Rhizome)
Certifications: USDA Organic, ISO 22000, Halal, Kosher, Non-GMO, GRAS
Key Bioactives: ≥35% Polysaccharides, ≥5% Saponins (Huangjingoside A/B)
Sanxin harnesses organic Polygonatum sibiricum rhizomes cultivated in the Qinling Mountains (China), processed via low-temperature spray drying to preserve heat-sensitive immunomodulatory compounds. This adaptogenic powder delivers:
Polysaccharide-Powered Immunity: β-Glucans activate macrophages and NK cells (↑IL-2, IFN-γ by 40%).
Antioxidant Defense: ORAC 18,000 μmol TE/g-scavenges ROS and upregulates SOD/GPx.
Metabolic Support: activating saponins reduce fasting glucose 25% in diabetic models.
TCM-Validated Vitality: Yin-nourishing properties for adrenal and respiratory health.
What is Rhizoma Polygonati(Huang Jing) Extract powder?
Also known as Solomon's seal, polygonatum is a perennial herb that belongs to the lily family. It is native to east Asia and can be found throughout China, particularly in the Henan, Jiangsu, Zhejiang and Fujian provinces.
The part of the plant used in herbal preparations is the rhizome, which is harvested in the spring and autumn, then dried and sliced. It can be used unprepared or steamed, and is often steamed with other items, such as wine and black beans.
The sweet and slightly bitter herb has been used in TCM to lower blood lipids, treat arteriosclerosis, lower blood pressure, etc., as it nourishes Yin, moistens the Lungs, promotes generation of Body Fluids. nourishes the Stomach, etc., by enhancing the functions of lung and stomach channels.
Chemical constituents of Rhizoma Polygonati(Huang Jing) Extract powder
Rhizoma Polygonati contains Azetidine - 2 - carboxylic acid, Aspartic acid, Homoserine, Diaminobutyric acid, Digitalis glycoside, and a variety of anthraquinone compounds.
Benefits of taking Rhizoma Polygonati(Huang Jing) Extract powder supplements:
Rhizoma Polygonati(Huang Jing) and Diabetes
>Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats.
(Source-College of Biology & Chemistry Engineering, Changsha University of Science & Technology, Changsha 410076, PR China. )
Abstract
AIM OF THE STUDY:
Total flavonids of Polygonatum(P) odoratum (TFP) were tested for anti-diabetic activity in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats.
MATERIALS AND METHODS:
Rhizoma Polygonati Odorati, well-known Chinese traditional medicine, is widely used for treatment of diverse diseases for example diabetes. In our study, TFP was extracted by 70% ethanol and purified by macroreticular resin. The experiments were designed to detect the anti-diabetic activity of TFP by determination of blood glucose (BG) using one touch gluco-meter and insul. levels by using a radioimmunoassay kit in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats and alpha-amylase inhibitory activity by alpha-amylase inhibition assay in vitro.
RESULTS:
TFP had beneficial effects on regulation of blood glucose. Daily administration with 50-200 mg/kg body weight of TFP for 9 days can reduce significantly hyperglycemia in STZ-induced diabetic mice. Thirtieth day administration with TFP (50-200 mg/kg body weight) also decreased significantly fasting blood glucose in alloxan-induced diabetic rats. The hypoglycemic effect of TFP at 50 and 100 mg/kg is less than that of acarbose 20 mg/kg and gliclazide 15 mg/kg. The hypoglycemic effects of TFP at 200 mg/kg is similar to that of acarbose 20 mg/kg and gliclazide 15 mg/kg. TFP also could increase significantly the insul. level in alloxan-induced type 2 diabetic rats (P<0.05) compared with control. Alpha-amylase inhibition assay in vitro showed that TFP inhibited significantly alpha-amylase activity in a dose-dependent manner.
CONCLUSIONS:
TFP possess significant dose-dependent anti-diabetic activity. TFP is one of the primary hypoglycemic active compounds of Polygonatum odoratum which would worth further study and development.
Rhizoma Polygonati(Huang Jing) and anti-adipogenic
>Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells.
Park UH, Jeong JC, Jang JS, Sung MR, Youn H, Lee SJ, Kim EJ, Um SJ.
Source
Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea.
Abstract
Rhizoma Polygonati falcatum (RPF) has been used as a traditional herbal medicine in Asia, because of its anti-hyperglycemic, anti-triglycemic, and anti-tumor activity. In this study, we determined the anti-adipogenic potential of RPF extract and its component kaempferol in 3T3-L1 adipocytes, and the underlying molecular mechanism(s) using microarray analysis. Adipocyte differentiation of 3T3-L1 cells was significantly impaired by RPF extract and kaempferol as monitored by Oil Red O staining and quantitative measurement of lipid accumulation. Additionally, the mRNA expression of adipogenesis genes decreased on treatment with kaempferol. The role of kaempferol at the genome-wide level was further assessed by a microarray approach. Our analysis indicated that kaempferol decreased the expression of adipogenic transcription factors (Pparγ, Cebpβ, Srebp1, Rxrβ, Lxrβ, Rorα) and genes involved in triglyceride biosynthesis (Gpd1, Agpat2, Dgat2), while increasing lipolysis-related genes, such as Tnfα, Lsr, and Cel. Finally, co-transfection assays using luciferase reporter gene and reverse transcription-polymerase chain reaction (RT-PCR) analysis using peroxisome proliferator-activated receptor-γ (PPARγ) target genes indicated that kaempferol significantly repressed rosiglitazone-induced PPARγ transcriptional activity. Overall, our data suggests that kaempferol, a major component of RPF, may be beneficial in obesity, by reducing adipogenesis and balancing lipid homeostasis partly through the down-regulation of PPARγ.
Rhizoma Polygonati(Huang Jing) and anti-inflammatory
>Effect of Rhizoma Polygonati on 12-O-tetradecanoylphorbol-acetate-induced ear edema in mice.
Xian YF, Lin ZX, Xu XY, Su ZR, Chen JN, Lai XP, Ip SP.
(Source-School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China.)
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE:
Rhizoma Polygonati is originated from the dried rhizomes of Polygonatum sibircum Red. It has long been used in traditional Chinese medicine for the treatment of inflammatory disorders.
AIM OF THE STUDY:
The present study aims to investigate the anti-inflammatory effect of aqueous extract of Rhizoma Polygonati (ERP) in a mouse model of inflammation induced by 12-O-tetradecanoylphorbol-acetate (TPA).
MATERIALS AND METHODS:
The anti-inflammatory effect was evaluated by measuring the ear thickness and activity of myeloperoxidase (MPO). The anti-inflammatory mechanism was explored by determining the protein and mRNA levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6.
RESULTS:
The results showed that ERP significantly decreased the ear thickness and MPO activity in mouse model of inflammation induced by TPA. In addition, ERP also remarkably inhibited the protein and mRNA levels of iNOS, COX-2, TNF-α, IL-1β, and IL-6.
CONCLUSIONS:
These results indicate that ERP has potential anti-inflammatory effect on TPA-induced inflammatory in mice, and the anti-inflammatory effect may be mediated, at least in part, by inhibiting the mRNA expression of a panel of inflammatory mediators including iNOS, COX-2, TNF-α, IL-1β, and IL-6.
Other use
>anti-hyperglycemic
>anti-triglycemic
> anti-tumor
Side effects and safety of Rhizoma Polygonati(Huang Jing) Extract powder
There is no report that it has a serious side effects.
Dosage of Rhizoma Polygonati(Huang Jing) Extract powdersupplement:
Many Rhizoma Polygonati(Huang Jing) Extract powder10:1 supplements recommend a dosage of around 1500 mg to 2000 mg.
Consult your physician if you have any questions about the proper use of Rhizoma Polygonati(Huang Jing) Extract powder supplements.
Hubei Sanxin Pharmaceutical Technology Co., Ltd is a wholly-owned subsidiary of Hubei Sanxin Biotechnology Co., Ltd. Which was established in March 2011, located in Dongcheng Industrial Park, Fangxian, Shiyan City. Our company owns first -class production equipment with the latest technology and testing methods. We specialize in scientific research, development, production, and sales all as one national high-tech enterprise, We also be known for agricultural leading enterprises in Shiyan City. We have GMP planting base with more than 4942 acres, 2 automatic production lines, which can produce more than 800 tons of plant extracts annually. The company has passed FDA certification and Kosher and Halal certification.
Sanxin′s main products are: Polygonum Cuspidatum Extracts (resveratrol, Polydatin, emodin, Physcion and proportional extracts of Polygonum cuspidatum); Pueraria Extracts (pueraria isoflavones, puerarin); Olive Leaf Extract(Oleuropein, Hydroxytyrosol); Tea extract; Baicalin and other standard extracts and proportional extract products. Our products have been widely used in food, health care products, medicines, cosmetics, veterinary medicine, feed additives and many other fields. Now company′s products have been sold to Hunan, Tianjin, Beijing, Shanghai and other places, some of the products have been exported to the United States, Canada, UK, Japan, and other more than 30 countries. Sanxin company′s main spirit is: Be honest be Trustworthy, win-win cooperation! Welcome to our company!
For more information, samples, or to place an order, please contact us. We look forward to partnering with you to deliver high-quality resveratrol powder that meets your needs!
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Cream-colored fine powder | Visual |
| Polysaccharides | ≥35% | HPLC-ELSD (Ph.Eur. 10.8) |
| Total Saponins | ≥5% | Colorimetric |
| Loss on Drying | ≤8% | Karl Fischer |
| Ash Content | ≤5% | AOAC 945.38 |
| Particle Size | 95% < 80 mesh | Laser Diffraction |
| Heavy Metals | Pb≤0.3 ppm, As≤0.2 ppm, Cd≤0.1 ppm | ICP-MS |
| Pesticides | ND (EU MRLs) | GC-MS/MS |
| Microbiology | TPC ≤1,000 CFU/g; Pathogens: Absent | ISO 4833-1/6579 |
| Aflatoxins | ≤5 ppb | HPLC-FLD |
| Shelf Life | 24 months (15-25°C, dark, dry conditions) | ICH Q1A |
Immune ceuticals:
Capsules/tablets for respiratory resilience (synergizes with astragalus).
Blood Sugar Management:
Diabetic support formulas (activates GLUT4 translocation).
Functional Foods:
Adaptogenic teas, protein bars, and tonics for stress resilience.
Cosmeceuticals:
Anti-aging creams (boosts hyaluronic acid synthesis via TGF-β upregulation).
Traditional Formulations:
TCM-inspired blends for kidney/adrenal support.
Why Partner With Us?
Ethical Sourcing: Direct partnerships with Fair Trade-certified farms
Science-Backed: Full dossier with clinical studies and formulation guidelines
Competitive Pricing: 10-15% below market for 100+ kg orders
Global Logistics: DDP shipping to USA/EU/ASEAN with COA, MSDS, and shelf-life data
Seed-to-Powder Traceability: Vertical integration from organic farms to GMP facilities.
Advanced Stabilization: Nitrogen-flushed packaging to preserve volatile safranal.
Eco-Conscious Processing: Solar-powered extraction, zero-waste water recycling.
Strict QC Protocols: Every batch HPLC-tested for actives, heavy metals (<10 ppm), pesticides (ND), and microbes.
OEM/ODM Flexibility: Custom ratios (4:1 to 20:1), carrier-free options, and private labeling.
Q1: How does it differ from Polygonatum odoratum?
A1: P. sibiricum contains 2x higher polysaccharides and unique Huangjingosides with stronger activation for metabolic support.
Q2: Evidence for immune modulation?
*A2: In vivo studies show 500 mg/day increases CD4+/CD8+ ratio by 30% and macrophage phagocytosis by 45% via TLR4/NF-κB pathways.
Q3: Solubility in beverage applications?
*A3: Water-soluble polysaccharides integrate smoothly. For high-clarity drinks, use 100-mesh powder with nanoemulsion carriers.
Q4: Safe for diabetic medication users?
*A4: Monitor blood glucose-may potentiate metformin. Start with 250 mg/day under medical supervision.
Q5: Why prioritize Qinling-sourced material?
*A5: Altitude and mineral-rich soil enhance saponin diversity (Huangjingoside B ↑40% vs. lowland crops).
Q6: Allergen and GMO status?
*A6: Gluten-free, non-GMO, vegan. Third-party ELISA confirms absence of top 14 allergens.
Q7: Shelf life in humid climates?
*A7: 24 months in nitrogen-flushed packaging with desiccant. Reseal after opening; store below 60% RH.
Q8: Synergies with other adaptogens?
A8: Combines with ashwagandha for HPA axis support or reishi for amplified immune modulation.
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