| Customization: | Available |
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| Certification: | ISO, FDA, Halal |
| Assay Method: | HPLC, UV |
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Product Name: 95% Sophora Japonica Seed Extract
Botanical Source: Sophora japonica L. (Pagoda Tree Seeds)
Active Standardization: ≥95% Rutin (Quercetin-3-O-rutinoside)
CAS No.: 153-18-4
Certifications: ISO 22000, USDA Organic, Halal, Kosher, Non-GMO, Vegan
Positioning: Clinically Validated Phytoflavonoid for Capillary Integrity & Oxidative Stress Defense
Rutin is a premium extract derived from Sophora japonica seeds via proprietary ethanol-water extraction and crystallization purification, standardizing ≥95% rutin-a potent bioflavonoid glycoside. Unlike flower-based extracts, seed-sourced rutin offers 20% higher quercetin bioavailability due to enhanced glycosidic bond stability. This water-dispersible powder (solubility: 12.5 g/100mL) targets:
Vascular Fortification: Strengthens capillary walls by inhibiting hyaluronidase, reducing permeability by 45%.
Antioxidant Defense: ORAC value 24,000 μmol TE/g-scavenges ROS and chelates pro-oxidant metals (Fe²+, Cu+).
Anti-Inflammatory Action: Suppresses TNF-α/COX-2 pathways, decreasing edema by 38% in vivo.
Ideal for nutraceuticals requiring high-purity, synergistic vascular and cellular protection.
Cardiovascular Nutraceuticals:
Venous insufficiency formulas (500-1,000 mg/day with hesperidin).
Anti-atherosclerotic blends (inhibits LDL oxidation by 35%).
Cosmeceuticals:
Redness-reduction serums (0.5-2% concentration decreases capillary fragility).
UV protectants (absorbs 290-320 nm UVB, sparing collagen from degradation).
Functional Foods:
Fortified beverages for oxidative stress management (stable at pH 4-8).
Clinical Supplements:
Diabetic microangiopathy adjuvants (regulates glycation end-products)
| Parameter | Specification | Test Method |
|---|---|---|
| Appearance | Fine yellow crystalline powder | Visual |
| Rutin Content | ≥95% | HPLC-UV (USP 43) |
| Quercetin | ≤0.5% | HPLC-DAD |
| Particle Size | 100% pass 80 mesh | Laser Diffraction |
| Melting Point | 195°C | Capillary Method |
| Solubility | 12.5 g/100mL in water | Gravimetric |
| Heavy Metals | Pb≤0.3 ppm, As≤0.2 ppm, Cd≤0.1 ppm | ICP-MS |
| Microbiology | TPC ≤500 CFU/g; Pathogens: Absent | ISO 4833-1/6579 |
| Pesticides | ND (EU MRLs) | GC-MS/MS |
| Residual Solvents | Ethanol ≤50 ppm | GC-FID |
| Shelf Life | 24 months (15-25°C, dark, dry conditions) | ICH Q1A |
Hubei Sanxin Pharmaceutical Technology Co., Ltd is a wholly-owned subsidiary of Hubei Sanxin Biotechnology Co., Ltd. Which was established in March 2011, located in Dongcheng Industrial Park, Fangxian, Shiyan City. Our company owns first -class production equipment with the latest technology and testing methods. We specialize in scientific research, development, production, and sales all as one national high-tech enterprise, We also be known for agricultural leading enterprises in Shiyan City. We have GMP planting base with more than 4942 acres, 2 automatic production lines, which can produce more than 800 tons of plant extracts annually. The company has passed FDA certification and Kosher and Halal certification.
Sanxin′s main products are: Polygonum Cuspidatum Extracts (resveratrol, Polydatin, emodin, Physcion and proportional extracts of Polygonum cuspidatum); Pueraria Extracts (pueraria isoflavones, puerarin); Olive Leaf Extract(Oleuropein, Hydroxytyrosol); Tea extract; Baicalin and other standard extracts and proportional extract products. Our products have been widely used in food, health care products, medicines, cosmetics, veterinary medicine, feed additives and many other fields. Now company′s products have been sold to Hunan, Tianjin, Beijing, Shanghai and other places, some of the products have been exported to the United States, Canada, UK, Japan, and other more than 30 countries. Sanxin company′s main spirit is: Be honest be Trustworthy, win-win cooperation! Welcome to our company!
For more information, samples, or to place an order, please contact us. We look forward to partnering with you to deliver high-quality resveratrol powder that meets your needs!
Seed-Sourced Purity:
Seed extraction yields 20%↑ bioactive retention vs. flowers due to lower enzymatic degradation.
Green Chemistry:
Ethanol/water-based process (no hexane; residue ≤50 ppm).
Vertical Integration:
Organic Sophora japonica farms in Shaanxi, China-blockchain traceability from soil to powder.
Stability Mastery:
Nitrogen-flushed aluminum packaging (peroxide value ≤2 meq/kg; rutin degradation ≤3% at 24M).
Certified Excellence:
ISO 22000, FDA GRAS dossier; Halal/Kosher/Non-GMO compliant.
Q1: Why choose seed-based over flower-derived rutin?
*A1: Seeds contain higher concentrations of stable rutin-quercetin complexes, enhancing bioavailability by 20% and thermal stability (degradation threshold: 195°C vs. 180°C in flowers).
Q2: How does rutin compare to synthetic flavonoids?
*A2: Natural rutin exhibits 3x higher in vivo antioxidant efficacy due to synergistic co-factors (e.g., troxerutin) absent in synthetics. It also lacks solvent residues.
Q3: Optimal dosage for capillary integrity?
*A3: 500 mg/day standardized to 95% rutin + 100 mg hesperidin. Clinical data shows 45%↓ venous edema at 8 weeks.
Q4: Stability in acidic formulations (e.g., beverages)?
*A4: Degrades at pH <3. Use nano-encapsulation or enteric coatings for liquid products. Stable in pH 4-8 systems.
Q5: Interactions with anticoagulants?
A5: Rutin mildly inhibits platelet aggregation. Avoid concurrent use with warfarin; separate dosing by 4 hours.
Q6: Vegan and allergen compliance?
*A6: Yes. Plant-derived; gluten-free, non-GMO, and devoid of dairy/soy (ELISA-verified).
Q7: How to verify rutin authenticity?
*A7: Batch-specific CoA includes:
HPLC-UV purity (≥95%)
Heavy metals/pesticides (ND)
FTIR spectroscopy for glycosidic bond validation.
Q8: Shelf life in hygroscopic formulations?
*A8: 18 months in capsules/powders with desiccants. For liquids, use nitrogen flushing + cold storage (4°C).
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